If you have access to a journal via a society or association membership, please browse to your society journal, select an article to view, and follow the instructions in this box. (b,c,d) Comparison of total FST for DD-associated single nucleotide polymorphisms (SNPs; blue line) compared with randomly permuted sets of SNPs. Finally, chromosome painting was used to see whether Dupuytren’s disease-associated single nucleotide polymorphisms are geographically structured. Table 1. Le travail manuel n’est pas responsable de la maladie de Dupuytren. If DD had been disseminated around Europe by the Norsemen, mention of it in one of these sources would be expected. enacademic.com EN. La maladie se manifeste surtout après la quarantaine et toucherait 6 fois plus souvent un homme qu’une femme. La Société canadienne de Dupuytren est présentement à la recherche d’un membre pour se joindre à notre comité de levée de fonds La société canadienne Dupuytren a été constituée et a reçu le statut d'organisme de bienfaisance en 2015. It is defined by Dorland as shortening, thickening, and fibrosis of the palmar fascia producing a flexion deformity of a finger. 2). Pour des raisons mal connues, ces tissus deviennent épais, se pelotonnent d’abord en boule (les nodules) ce qui entraîne des plis dans la paume ou les doigts. For each comparator group, the total FST of the DD-associated SNPs was not within the top 5% of ranked total FST of 10,000 permuted SNP groups (nominally p > 0.05, Figure 1(b,c,d). Get the News Letter from Dupuytren Research Group, Information for Scientists and Clinicians, Dupuytren Research Group 2012 Research Grants. forum pour la maladie de Dupuytren et maladie de Ledderhose; Dupuytren Society ... Dupuytren Society se réserve le droit de supprimer tout message contenant de la publicité, ainsi que toute information dont le contenu serait illicite ou inadéquat. This site uses cookies. La maladie de Dupuytren ou contracture de Dupuytren est une fibrose rétractile de l'aponévrose palmaire (une membrane située entre les tendons fléchisseurs et la peau). Plater described a stone mason with “contraction of the fingers of the left hand into the palm” [1]. People of the British Isles: preliminary analysis of genotypes and surnames in a UK-control population, The British Society for Surgery of the Hand. What is the natural course of the disorder with no treatment? Les modérateurs de ce forum sont des bénévoles et Dupuytren e.V. ... L’origine de cette maladie est encore inconnue, elle peut être d’origine génétique et pouvant atteindre plusieurs membres d’une famille. La maladie de Dupuytren est une sclé-rose rétr actile de l aponévrose palmaire moyenne, pouv ant entr aîner la flexion progressive et irréductible d un ou plu- ... leur origine au nive au du tendon long palmaire ou, si ce tendon est absent, au niveau des fibres de l aponévrose antébrac hiale. For the case-control analysis, the total genomic FST was calculated for each individual case or control using the formula: Second, the total FST of the DD-associated SNPs from BSSH-GODD was calculated and compared with the total FST of 10,000 randomly generated permutations of SNP groups of the same size, to generate an empirical p-value for the ‘Viking origin’ of DD-associated SNPs. The ‘Viking Disease’ The frequency of Dupuytren’s disease is high in many northern European countries where the Vikings settled and thus it is often nicknamed ‘The Viking Disease’. Furthermore, Elliot (1988) also comments on the lack of records of DD in the medical writings of the missionaries of Iona, the Roman Church in North Germany and North-East England, or the extensive medical writings from mediaeval Europe. FST for each SNP was calculated using Hudson’s estimator of FST (Hudson et al., 1992), as implemented in EIGENSOFT (https://www.hsph.harvard.edu/alkes-price/software/). Compared with previous reports (Whaley and Elliot, 1993), our data provide objective evidence of the lack of Norse origin of the disease. LA MALADIE DE DUPUYTREN. La maladie de Dupuytren est une maladie d`origine inconnue qui. There are three major historical sources of this population structure: north-west Germany, France and Spain, with the greatest contribution observed in the current population of rural Wales; northern Germany and Denmark, with the greatest contribution observed in the population of rural south-east England; and the Norse, with the greatest contribution observed in the population of the Orkney Islands. It sounds believable. In many cases it is believed to be associated with other medical conditions, although the evidence for such associations is not always clear. The Papal Benediction sign, with bent ring and small fingers, may have started with a pope with the condition 10050238. Contact us if you experience any difficulty logging in. Next, to assess for localized population structure at the DD-associated loci in the PoBI dataset, we used chromosome painting, comparing the frequency of haplotypes most recently shared within population groups to that between population groups (Lawson et al., 2012). Maladie de Dupuytren La maladie de Dupuytren est une affection de la main caractérisée par une flexion progressive et irréductible de certains doigts. The second stream of evidence is historical. In addition, we thank the surgeons and researchers in the BSSH-GODD study who helped with recruitment of affected individuals. La maladie de Dupuytren est une maladie qui touche généralement les personnes âgées, mais elle peut apparaître dès l’âge de 40 ans environ. La maladie de Dupuytren est caractérisée par une rétraction des doigts secondaire à une prolifération de tissu fibreux rétractile dans l’aponévrose palmaire et ses prolongements dans les doigts. Bien que cela ne soit pas totalement certain, cette maladie c’est diffusée surtout en Europe lors des invasions Viking, elle peut prendre des formes variables touchant les mains, les pieds (maladie de Ledderhose) et la verge (maladie de Lapeyronie). Table 2. Please check you selected the correct society from the list and entered the user name and password you use to log in to your society website. Il s’agit d’une fibrose rétractile de l’aponévrose palmaire moyenne de la main qui est une membrane située entre les tendons fléchisseurs de la main et la peau. L'affection est souvent bilatérale. James Barrie, author of “Peter Pan” had a right contracture thought to be Dupuytren’s, which formed the source material for Captain Hook’s hook. Pour des raisons mal connues, ces tissus deviennent épais, se pelotonnent d'abord en boule (les nodules) ce qui entraîne des plis dans la paume ou les doigts. Figure 2. On pense que la maladie de Dupuytren a une origine nordique et ce sont les invasions des Vikings au 12 e siècle qui aurait propagé le gène en Europe et dans les colonies françaises et anglaises. Six gènes en rapport avec la maladie ont été mis en évidence. La maladie de Dupuytren (également connue sous le nom de contracture de Dupuytren) est un état bénin de la peau caractérisée par la surcroissance des myofibroblasts English new terms dictionary; Interpretations; Translations; Books; English new terms dictionary  Dupuytren's contracture. La pathogenèse de la maladie de Dupuytren repose sur leur s tructure tridimensionnelle. This product could help you, Accessing resources off campus can be a challenge. Elle est plus fréquente chez les hommes, les diabétiques ou en cas de consommation chronique d’alcool. En effet les patients atteints de la maladie de Dupuytren notamment serait plus enclin à développer une maladie de Lapeyronie (l’association Dupuytren – maladie de lapeyronie a été retrouvée dans 10 à 15% des cas). For more information view the SAGE Journals Sharing page. If DD were of Norse origin, we would expect that the total FST of our disease-associated SNPs would be higher than randomly generated groups of SNPs. Sign in here to access free tools such as favourites and alerts, or to access personal subscriptions, If you have access to journal content via a university, library or employer, sign in here, Research off-campus without worrying about access issues. The permuted sets of random SNPs were ranked by total FST and we examined where in this list the set of DD-associated SNPs was ranked. En 1831, Guillaume Dupuytren était considéré comme le plus grand chirurgien d’Europe ().Sa présentation orale d’un cas de « rétraction des doigts par suite d’une affection de l’aponévrose palmaire » eut un retentissement immédiat en France et en Angleterre et fut à l’origine d’une polémique sur son étiologie et son traitement qui n’est pas encore terminée. Happy Thanksgiving from The Dupuytren Research Group. Members of _ can log in with their society credentials below, Journal of Hand Surgery (European Volume), Michael Ng, Daniel J Lawson, Bruce Winney, and Dominic Furniss, This article is distributed under the terms of the Creative Commons Attribution 4.0 License (. Dupuytren disease has been referred to as a Viking or Celtic disease, but existed in Europe earlier than the Viking Age8345270 and originated much earlier in prehistory 12015711 . Data used in this study are available from the European Genome-Phenome Archive (https://ega-archive.org), study numbers EGAS00001000672 and EGAS00001001206, The distribution of genomic FST in both cases and controls closely followed a normal distribution (Figure 1(a)). (J Hand Surg 2002;27A:385–390. Les choix therapeutiques restent donc incertains comme en temoigne la multiplicite des techniques chirurgicales et des … Wright’s Fixation Index (FST) analysis reveals no evidence of a Norse origin of Dupuytren’s Disease (DD). Briefly, the BSSH-GODD study included a total of 7912 cases of DD and 12,937 population-based controls. Login failed. Hygiène au cabinet médical. En 1831, le baron Guillaume Dupuytren fut le premier à décrire en détail cette affection caractérisée par des contractures digitales, et le premier aussi à les traiter chirurgicalement. Furthermore, the lack of description of a disease resembling DD in Ancient Greek, Roman, Early Anglo-Saxon or Medieval European writings is further putative evidence of a Nordic origin of the disease (Elliot, 1988). Finally, we constructed a genetic risk score (GRS) for DD and applied it to the PoBI dataset, hypothesizing that people from those regions of known high Norse ancestry would have a higher GRS than those from areas with low levels of Norse ancestry. The e-mail addresses that you supply to use this service will not be used for any other purpose without your consent. Maladie de Dupuytren : définition C'est une fibrose rétractile irréductible de l'aponévrose palmaire de la main avec rétraction et flexion des doigts, perception de nodules durs et épaississement de l'aponévrose palmaire moyenne. The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. La maladie de Dupuytren est une maladie d’origine inconnue qui touche des tissus (les aponévroses) dont le rôle est de protéger les muscles, les nerfs et les vaisseaux. Le traitement classique était chirurgical, … We identified the common SNPs between the PoBI dataset and BSSH-GODD dataset and removed multi-allelic SNPs and non-autosomal SNPs, leaving a set of 462,930 SNPs for further analysis. Pour des raisons mal connues, ces tissus deviennent épais, se pelotonnent d’abord en boule (les nodules) ce qui entraîne des plis dans la paume ou les doigts. ,{i:'fig2-1753193419882851',type:'fig',g:[{m:'10.1177_1753193419882851-fig2.gif',l:'10.1177_1753193419882851-fig2.jpeg',size:'1 MB'}]} See Table 1 for an explanation of the terms used in this study. window.figureViewer={doi:'10.1177/1753193419882851',path:'/na101/home/literatum/publisher/sage/journals/content/jhsc/2020/jhsc_45_3/1753193419882851/20200212',figures:[{i:'table1-1753193419882851',type:'table-wrap',g:[{m:'10.1177_1753193419882851-table1.gif',l:'10.1177_1753193419882851-table1.jpeg',size:'616 KB'}]} Dupuytren's disease typically starts at the age of 50 to 60, though even children have been reported to suffer from Dupuytren's disease (example of a 10 year old boy: "Dupuytren's disease in a child: a case report" Dupuytren_child_abstract). Dupuytren’s disease, Morbus Dupuytren or palmar fibromatosis, sometimes also called DD, Dupuytren’s contracture, or Viking disease, is a chronic disease that produces a benign thickening of the connective tissue, or fascia, of the palm and fingers. the site you are agreeing to our use of cookies. We then aggregated these scores across the 35 population labels to investigate possible geographical structure associated with known regions of high Norse ancestry, such as the Highlands of Scotland. First, we compared the summed total FST for Norse ancestry informative markers from PoBI in cases and controls in BSSH-GODD. http://www.creativecommons.org/licenses/by/4.0/, https://us.sagepub.com/en-us/nam/open-access-at-sage, https://www.hsph.harvard.edu/alkes-price/software/, Common variants of the ALDH2 and DHDH genes and the risk of Dupuytren’s disease, Radiotherapy in Dupuytren’s disease: a systematic review of the evidence, Egawa T, Senuri S, Horiki A, Egawa M. Epidemiology of the Oriental patient. Fiche de conseils Dupuytren. Cet épaississement s’accompagne d’une rétraction qui limite l’extension des doigts et peut infiltrer la peau. The earliest reference that we found in the medical literature to the condition that ultimately came to be known as Dupuytren’s Disease was a report by Felix Plater in the 17 th century. Elles s … La maladie de Dupuytren est une maladie évolutive, dont la vitesse d’évolution peut aller de quelques mois à plusieurs années. Total FST of the remaining 21 DD-associated SNPs was calculated, using each of the three comparator groups. Is Dupuytren’s disease really a ‘disease of the Vikings’? hygiène des mains. Compared with 500 random samples of 21 SNPs taken from across the genome, the DD-associated SNPs do not show an increase in within-population structure (p = 0.072, Figure 2(a)), which would have been expected had DD been associated with Norse ancestry. Cette vidéo traite de la maladie de Dupuytren: et des soins naturels les plus efficaces à mettre en oeuvre dès l"apparition des troubles. Tradition has it that the disease originated with the Vikings, who spread it throughout Northern Europe and beyond as they traveled and intermarried. We used recently reported genetic association results from the British Society for Surgery of the Hand Genetics of Dupuytren’s Disease (BSSH-GODD) (Ng et al., 2017) to provide empirical evidence to investigate whether DD is associated with Norse ancestry. Why Is Dupuytren's Contracture Called Viking Disease? The mean difference in total FST between cases and controls ranged between −0.06 and 0.05 (Table 2). L’atteinte d’autres membres de la famille, avec des formes de sévérité variable, semble indiquer une origine génétique. Some society journals require you to create a personal profile, then activate your society account, You are adding the following journals to your email alerts, Did you struggle to get access to this article? The PoBI dataset consisted of a geographically diverse sample of 2039 individuals from the United Kingdom, which were then compared with 6209 individuals from across Europe to generate signals of historical demographic shifts. If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. For the permutation analysis, we first determined the SNPs to represent each of the 26 credible sets associated with DD. We then permuted 10,000 random sets of 21 SNPs within the PoBI dataset and calculated the total FST of each of these sets in each of the three comparator groups. Les invasions des Vikings restent le facteur … ]}. Townley, WA, Baker, R, Sheppard, N, Grobbelaar, AO. Finally, a GRS derived from DD-associated SNPs did not show increased geographical clustering around areas of known high Norse ancestry. La maladie de Dupuytren est une maladie d’origine inconnue qui touche des tissus (les aponévroses) dont le rôle est de protéger les muscles, les nerfs et les vaisseaux. Dupuytren's disease is currently called a Viking disease on the assumption that the disease was spread to Europe and the British Isles during the Viking Age of the 9th to the 13th centuries. To make a fair null hypothesis, we sampled the same number of random genome-wide SNPs that make up the risk score using 500 random samples of 21 SNPs. The authors wish to acknowledge all of the individuals who participated in both studies. La Scandinavie et toutes les populations ayant été en contact avec les Vikings, lors des migrations, témoignent encore aujourd'hui du patrimoine génétique qu'ils ont légué au travers de pathologies héréditaires... car la maladie de Dupuytren n'est pas la seule maladie transmise par les vikings. contact » ou porteur d`Entérocoque. Fiche Canal Carpien - Institut de la main. Cette maladie est en partie d’origine génétique et apparaît le plus souvent vers la cinquantaine chez l’homme et plus tardivement chez la femme. Furthermore, chromosome painting did not find evidence for localized genetic population structure that would be expected around DD-associated SNPs if there were an excess of Norse ancestry. Cette pathologie touche notamment les hommes âgés de plus de 40 ans et également les diabétiques. History of Dupuytren's disease Early History of Dupuytren’s Disease and Surgical Treatments. The authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: DF was supported by an Intermediate Clinical Fellowship from the Wellcome Trust [097152/Z/11/Z]. Dupuytren’s disease (DD) is a disease of the palmar fascia that causes flexion contractures of the fingers (Townley et al., 2006). mémoire de la … There has been a much quoted concept of DD being labeled as the “Viking“ or “Nordic“ disease. L’analyse statistique a été faite sur logiciel Epi info et SPSS. Mesures d`hygiène : tenue de base, précautions. To ensure that this method has power, we selected a positive control by repeating this analysis for a Lactase-associated SNP – rs4988235 in MCM6. En règle générale, la quantité d’alcool consommée (volume, fréquence et durée) détermine le risque et la gravité des lésions hépatiques. The entire cohort was plotted against theoretical quantiles to demonstrate the normality of the data (upper right panel). Local haplotype structure does not support a Viking introgression of Dupuytren’s disease into the British Isles. L'étiologie est inconnue, l'atteinte est souvent bilatérale, les tendons fléchisseurs des doigts sont indemnes, ce ne sont pas eux qui se rétractent. Elle se caractérise par une rétraction fibreuse de l’aponévrose palmaire moyenne entraînant une rétraction progressive et irréductible des doigts. The People of the British Isles (PoBI) Study sampled DNA from 2039 individuals throughout rural areas of the UK whose four grandparents were born within 80 km of each other (Winney et al., 2012). D’autres pathologies d’altération de gènes responsables de dégradation du collagène ont été également retrouvées. Access to society journal content varies across our titles. On pense que la maladie de Dupuytren a une origine nordique et ce sont les invasions des Vikings au 12e siècle qui aurait propagé le gène en Europe et dans les colonies françaises et anglaises. It is named after Guillaume Dupuytren, who first described the underlying mechanism of action followed by the first successful operation in 1831 and publication of the results in The Lancet in 1834. We hypothesized that if DD were of Norse origin, cases would have a higher average total FST than controls. La maladie de Dupuytren est pratiquement inexistante en Afrique et en Asie. It’s also a complete fantasy. Bien que cela ne soit pas totalement certain, cette maladie c’est diffusée surtout en Europe lors des invasions Viking, elle peut prendre des formes variables touchant les mains, les pieds (maladie de Ledderhose) et la verge (maladie de Lapeyronie). On l'appelle aussi parfois "la maladie des Vikings" car elle touche majoritairement les hommes d'Europe du Nord, de plus de 40 ans. It has been suggested that Dupuytren’s disease has an origin in Norse countries. We computed Wright’s Fixation Index between Orkney (Norse ancestry), Wales (ancient British) and South East England (Anglo-Saxons); compared mean Wright’s Fixation Index in cases versus controls; used permutation to determine any excess of Norse inheritance in disease associated variants; constructed a genetic risk score for Dupuytren’s disease and applied this to the People of the British Isles dataset to look for systematic differences between counties with known high and low levels of Norse ancestry. Origin C19: named after the French surgeon Baron Guillaume Dupuytren. Dupuytren's disease: what dermatologists need to know. La prédisposition génétique de cette maladie est actuellement établie de façon irréfutable. Viking legacy makes a great story. First, epidemiological studies have shown that DD is more common in European populations and the prevalence seems to be highest in Iceland and Scandinavian countries that were the origin of the Viking Warriors (Hindocha et al., 2009). (b) Lactase-associated SNP rs4988235 shows a highly significant decrease in local haplotype sharing. In all analyses, no evidence was found for an excess of Norse ancestry in Dupuytren’s disease. The GRS for DD from the 21 independent Dupuytren’s GWAS hits was calculated for each individual in the PoBI dataset. A nominal threshold of significance of 0.05 was set, with the hypothesis that if DD is associated with Norse ancestry, the total FST of the DD-associated SNP set would be in the top 5% of permuted sets. Origines et signes de la maladie. Other phenotypes, such as educational attainment, show strong associations with geography on this scale (Timpson et al., 2018). Add to this the known prehistoric cases (like the Egyptian mummy) that are clearly … Happy Holidays from the Dupuytren Research Group! Dupuytren’s disease (DD) is an ancient affliction of unknown origin. ,{i:'table2-1753193419882851',type:'table-wrap',g:[{m:'10.1177_1753193419882851-table2.gif',l:'10.1177_1753193419882851-table2.jpeg',size:'102 KB'}]} However, there are nine or ten different genes associated with Dupuytren’s and this suggests that it may have evolved on several different occasions. les bons gestes. Tradition has it that the disease originated with the Vikings, who spread it throughout Northern Europe and beyond as they traveled and intermarried. Our results do not provide support for the hypothesis that DD is a ‘disease of the Vikings’. Elles Pour des raisons mal connues, ces tissus deviennent épais, se pelotonnent d'abord en boule (les nodules) ce qui entraîne des plis dans la paume ou les doigts. Résultats L’échantillon concerne 3025 agents. Lactase is under positive selection and therefore has much less population-specific haplotype sharing. Exceptionnelle chez les Asiatiques (1 seul cas), les Africains (à peine 8 cas répertoriés) et les Indiens (10 cas décrits) , la maladie de Dupuytren survient seulement chez les sujets blancs, européens du nord (Islande, Scandinavie, Russie, Angleterre) et chez leurs descendants, en particulier dans les pays d'émigration britannique (Canada, États-Unis, Australie). The PoBI dataset was searched for the statistically most highly associated SNP from each credible set. Within the UK there are geographical population clusters that can be separated on the basis of their inherited genetic variation (Leslie et al., 2015). If DD were of Norse origin, we would expect that cases would have a higher average total FST than controls. View or download all the content the society has access to. For more information view the SAGE Journals Article Sharing page. Toutefois, aucun lien de cause à effet n'a été démontré entre ces deux maladies. The first nickname comes from the belief that the condition originated among the Vikings (inhabitants in Scandinavian countries: Denmark, Norway, and Sweden). The Papal Benediction sign, with bent ring and small fingers, may have started …

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